Chemical Evolution of Autotaxin Inhibitors

Chemical Evolution of Autotaxin Inhibitors

(ATX or ENPP2) was isolated as an autocrine motility factor from melanoma cells. 1 The ∼120 kDa glycoprotein ATX belongs to a small family named ectonucleotide pyrophosphatase and phosphodiesterase (ENPP), which consists of seven family members. 2 ATX is the only ENPP family member with lysophospholipase D (lysoPLD) activity and is responsible for the hydrolysis of lysophosphatidylcholine (LPC)...

Autotaxin: inhibiting a greasy pocket Medicinal significance of autotaxin

Autotaxin (ATX) is a secreted glycoprotein that has been implicated in various physiological and pathophysiological processes, including vascular and neural development, lymphocyte trafficking, fibrosis and tumour progression. ATX functions as lysophopholipase D (lysoPLD), hydrolysing lysophosphatidylcholine (LPC) into the signalling lipid lysophosphatidic acid (LPA). LPA stimulates cell migrat...

Chemical Evolution

Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion.

Autotaxin (ATX) is a prometastatic enzyme initially isolated from the conditioned medium of human melanoma cells that stimulates a myriad of biological activities, including angiogenesis and the promotion of cell growth, survival, and differentiation through the production of lysophosphatidic acid (LPA). ATX increases the aggressiveness and invasiveness of transformed cells, and ATX levels dire...

Models of Chemical Evolution

The basic principles underlying galactic chemical evolution and the most important results of chemical evolution models are discussed. In particular, the chemical evolution of the Milky Way galaxy, for which we possess the majority of observational constraints, is described. Then, it is shown how different star formation histories influence the chemical evolution of galaxies of different morpho...